A Skeptic's Guide to Bacterial Mechanosensing

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Article

Chewla, Ravi¹  Gupta, Rachit¹  Lele, Tanmay P.²  Lele, Pushkar P.¹ 

[1] Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA

[2] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA

关键词: Surface-sensing;    Motility;    Appendages;    Viscous load;    Motors;   

DOI  :  10.1016/j.jmb.2019.09.004

来源: Elsevier

【 摘 要 】

Surface sensing in bacteria is a precursor to the colonization of biotic and abiotic surfaces, and an important cause of drug resistance and virulence. As a motile bacterium approaches and adheres to a surface from the bulk fluid, the mechanical forces that act on it change. Bacteria are able to sense these changes in the mechanical load through a process termed mechanosensing. Bacterial mechanosensing has featured prominently in recent literature as playing a key role in surface sensing. However, the changes in mechanical loads on different parts of the cell at a surface vary in magnitudes as well as in signs. This confounds the determination of a causal relationship between the activation of specific mechanosensors and surface sensing. Here, we explain how contrasting mechanical stimuli arise on a surface-adherent cell and how known mechanosensors respond to these stimuli. The evidence for mechanosensing in select bacterial species is reinterpreted, with a focus on mechanosensitive molecular motors. We conclude with proposed criteria that bacterial mechanosensors must satisfy to successfully mediate surface sensing. (C) 2019 The Author(s). Published by Elsevier Ltd.

【 授权许可】

Free