Phospholipids in Autophagosome Formation and Fusion

JOURNAL OF MOLECULAR BIOLOGY

卷:428

Review

Martens, Sascha¹  Nakamura, Shuhei²  Yoshimori, Tamotsu² 

[1] Univ Vienna, Max F Perutz Labs, Dept Biochem & Cell Biol, Dr Bohr Gasse 9-3, A-1030 Vienna, Austria

[2] Osaka Univ, Dept Genet, Grad Sch Med, Yamadaoka 2-2, Suita, Osaka 5650871, Japan

关键词: autophagy;    lysosome;    conjugation;    phosphatidylethanolamine;    phosphatidylinositol 3-phosphate;   

DOI  :  10.1016/j.jmb.2016.10.029

来源: Elsevier

【 摘 要 】

Autophagosomes are double-membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein lipid interactions. While most studies focus on the proteins involved in autophagosome formation, it is obvious that lipids including phospholipids, sphingolipids, and sterols play an equally important role. Here, we summarize the current knowledge about the role of lipids, especially focusing on phospholipids and their interplay with the autophagic protein machinery during autophagosome formation and fusion. (C) 2016 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free