Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2

JOURNAL OF INVESTIGATIVE DERMATOLOGY

卷:121

Article

Lee, EH ; Cho, SY ; Kim, SJ ; Shin, ES ; Chang, HK ; Kim, DH ; Yeom, MH ; Woe, KS ; Lee, J ; Sim, YC ; Lee, TR

关键词: apoptosis;    Bcl-2;    ginsenoside F1;    HaCaT;    ultraviolet B;   

DOI  :  10.1046/j.1523-1747.2003.12425.x

来源: Elsevier

【 摘 要 】

Ginsenosides, the major active ingredients of ginseng, show a variety of biomedical efficacies such as antiaging and antioxidation. Here, we investigate the protective activity of the ginsenoside F1, an enzymatically modified derivative of ginsenoside Rg1, against ultraviolet-B-induced damage in human HaCaT keratinocytes. Ginsenoside F1 significantly reduced ultraviolet-B-induced cell death and protected HaCaT cells from apoptosis caused by ultraviolet B irradiation. Furthermore, ginsenoside F1 prevented ultraviolet-B-induced cleavage of poly( ADP-ribose) polymerase in HaCaT cells. In search of the molecular mechanism responsible for the antiapoptotic effect of ginsenoside F1, we find that protection from ultraviolet-B-induced apoptosis is tightly correlated with ginsenoside-F1-mediated inhibition of ultraviolet-B-induced downregulation of Bcl-2 and Brn-3a expression.

【 授权许可】

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