期刊论文详细信息
JOURNAL OF INVESTIGATIVE DERMATOLOGY 卷:123
Regulation of involucrin gene expression
Review
Eckert, RL ; Crish, JF ; Efimova, T ; Dashti, SR ; Deucher, A ; Bone, F ; Adhikary, G ; Huang, GS ; Gopalakrishnan, R ; Balasubramanian, S
关键词: AP1;    C;    EBP;    differentiation;    ERK;    gene expression;    keratinocyte;    MAPK;    p38;    protein kinase C;   
DOI  :  10.1111/j.0022-202X.2004.22723.x
来源: Elsevier
PDF
【 摘 要 】

The epidermis is a dynamic renewing structure that provides life-sustaining protection from the environment. The major cell type of the epidermis, the epidermal keratinocyte, undergoes a carefully choreographed program of differentiation. Alteration of these events results in a variety of debilitating and life-threatening diseases. Understanding how this process is regulated is an important current goal in biology. In this review, we summarize the literature regarding regulation of involucrin, an important marker gene that serves as a model for understanding the mechanisms that regulate the differentiation process. Current knowledge describing the role of transcription factors and signaling cascades in regulating involucrin gene expression are presented. These studies describe a signaling cascade that includes the novel protein kinase C isoforms, Ras, MEKK1, MEK3, and a p38delta-extracellular signal regulated kinase 1/2 complex. This cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression.

【 授权许可】

Free   

【 预 览 】
附件列表
Files Size Format View
10_1111_j_0022-202X_2004_22723_x.pdf 413KB PDF download
  文献评价指标  
  下载次数:0次 浏览次数:0次