Transglutaminase function in epidermis

JOURNAL OF INVESTIGATIVE DERMATOLOGY

卷:124

Review

Eckert, RL ; Sturniolo, MT ; Broome, AM ; Ruse, M ; Rorke, EA

关键词: calcium;    differentiation;    epidermis;    involucrin;    keratinocyte;    transglutaminase;   

DOI  :  10.1111/j.0022-202X.2005.23627.x

来源: Elsevier

【 摘 要 】

Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.

【 授权许可】

Free