Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:129

Review

Serra-Blasco, Maria^1,3,30  Radua, Joaquim^2,4,5,6,30  Soriano-Mas, Carles^7,8,30  Benlloch, Alba Gomez⁹  Porta-Caster, Daniel¹  Carulla-Roig, Marta¹⁰  Albajee-Eizagirre, Anton⁴  Arnone, Danilo^11,12,16  Klauser, Paul^13,14,15  Canales-Rodriguez, Eric J.^17,18  Hilbert, Kevin¹⁹  Wise, Toby^20,21  Cheng, Yuqui²²  Kandilarova, Sevdalina^23,24  Mataix-Cols, David^25,26  Vieta, Eduard^4,6,30  Via, Esther^27,28  Cardoner, Narcis^29,30 

[1] Hosp Univ Parc Tauli, Inst Invest & Innovaci Parc Tauli I3PT, Dept Mental Hlth, Barcelona, Spain

[2] Abat Oliba CEU Univ, Dept Psychol, Barcelona, Spain

[3] Inst Catala Oncol, Programa E Hlth ICOnnectat, Barcelona, Spain

[4] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[6] Hosp Clin Barcelona, Barcelona Bipolar Disorders & Depress Unit, Inst Neurosci, Barcelona, Spain

[7] Bellvitge Univ Hosp, Inst Invest Biom edica Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain

[8] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain

[9] Hosp Gen Granollers, Barcelona, Spain

[10] Hosp San Juan Dios, Dept Psychiat & Psychol, Passeig Sant Joan Deu,2,Esplugues Llobregat, Barcelona 08950, Spain

[11] United Arab Emirates Univ UAEU, Dept Psychiat & Behav Sci, Coll Med & Hlth Sci, Abu Dhabi, U Arab Emirates

[12] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Affect Disorders Psychol Med, London, England

[13] Lausanne Univ Hosp CHUV, Dept Psychiat, Ctr Psychiat Neurosci, Lausanne, Switzerland

[14] Lausanne Univ Hosp CHUV, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Switzerland

[15] Monash Univ, Turner Inst Brain & Mental Hlth, Clayton, Vic, Australia

[16] Monash Univ, Sch Psychol Sci, Clayton, Vic, Australia

[17] Germanes Hosp, FIDMAG Res Fdn, Barcelona, Spain

[18] Ecole Polytech Fed Lausanne EPFL, Signal Proc Lab LTS5, Lausanne, Switzerland

[19] Humboldt Univ, Dept Psychol, Berlin, Germany

[20] UCL, Max Planck UCL Ctr Computat Psychiat & Ageing Res, London, England

[21] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA

[22] Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China

[23] Med Univ Plovdiv, Dept Psychiat & Med Psychol, Plovdiv, Bulgaria

[24] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria

[25] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[26] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden

[27] Hosp San Juan Dios, Child & Adolescent Psychiat & Psychol Dept, Barcelona, Spain

[28] Inst Recerca Sant Joan Deu, Child & Adolescent Mental Hlth Res Grp, Barcelona, Spain

[29] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Spain

[30] Carlos III Hlth Inst, Mental Hlth Networking Biomed Res Ctr CIBERSAM, Madrid, Spain

关键词: Major depressive disorder;    Anxiety disorders;    Posttraumatic stress disorder;    Comorbidities;    Gray matter volume;    Meta-analysis;    Structural neuroimaging;    Neurphyiatry;   

DOI  :  10.1016/j.neubiorev.2021.07.002

来源: Elsevier

【 摘 要 】

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

【 授权许可】

Free