Dysfunction of sensory oscillations in Autism Spectrum Disorder

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:68

Review

Simon, David M.¹  Wallace, Mark T.^2,3,4,5,6 

[1] Vanderbilt Univ, Neurosci Grad Program, 221 Kirkland Hall, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Vanderbilt Brain Inst, 221 Kirkland Hall, Nashville, TN 37235 USA

[3] Vanderbilt Univ, Dept Hearing & Speech Sci, 221 Kirkland Hall, Nashville, TN 37235 USA

[4] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA

[5] Vanderbilt Univ, Dept Psychiat, 221 Kirkland Hall, Nashville, TN 37235 USA

[6] Vanderbilt Univ, Vanderbilt Kennedy Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA

关键词: Autism Spectrum Disorder;    Oscillation;    Perception;    Sensory processing;    Synchronization;   

DOI  :  10.1016/j.neubiorev.2016.07.016

来源: Elsevier

【 摘 要 】

Autism Spectrum Disorder (ASD) is a highly prevalent developmental disability characterized by deficits in social communication and interaction, restricted interests, and repetitive behaviors. Recently, anomalous sensory and perceptual function has gained an increased level of recognition as an important feature of ASD. A specific impairment in the ability to integrate information across brain networks has been proposed to contribute to these disruptions. A crucial mechanism for these integrative processes is the rhythmic synchronization of neuronal excitability across neural populations; collectively known as oscillations. In ASD there is believed to be a deficit in the ability to efficiently couple functional neural networks using these oscillations. This review discusses evidence for disruptions in oscillatory synchronization in ASD, and how disturbance of this neural mechanism contributes to alterations in sensory and perceptual function. The review also frames oscillatory data from the perspective of prevailing neurobiologically-inspired theories of ASD. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free