Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:76

Article

Silveira, Mason M.¹  Arnold, Jonathon C.^2,3  Laviolette, Steven R.^4,5  Hillard, Cecilia J.⁶  Celorrio, Marta^7,8  Aymerich, Maria S.^7,8,9  Adams, Wendy K.¹ 

[1] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Dept Psychol, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada

[2] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia

[3] Univ Sydney, Discipline Pharmacol, Sydney, NSW, Australia

[4] Univ Western Ontario, Schulich Sch Med & Dent, Addict Res Grp, London, ON, Canada

[5] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON, Canada

[6] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Neurosci Res Ctr, Milwaukee, WI 53226 USA

[7] Univ Navarra, Ctr Appl Med Res CIMA, Program Neurosci, Pamplona 31008, Spain

[8] Univ Navarra, Sch Sci, Dept Biochem & Genet, Pamplona 31008, Spain

[9] Navarra Inst Hlth Res, IdiSNA, Pamplona 31008, Spain

关键词: Cannabis;    Phytocannabinoids;    Endocannabinoid system;    THC;    Cannabidiol;    CB1 receptor;    AEA;    FAAH;    Corticolimbic circuits;    Prefrontal cortex;    Amygdala;    Hippocampus;    Mesolimbic dopamine system;    Individual differences;    Decision making;    Social interaction;    Emotional salience processing;    Anxiety;    Elevated plus maze;    Psychiatric disorders;   

DOI  :  10.1016/j.neubiorev.2016.09.007

来源: Elsevier

【 摘 要 】

Public opinion surrounding the recreational use and therapeutic potential of cannabis is shifting. This review describes new work examining the behavioural and neural effects of cannabis and the endo-cannabinoid system, highlighting key regions within corticolimbic brain circuits. First, we consider the role of human genetic factors and cannabis strain chemotypic differences in contributing to interindividual variation in the response to cannabinoids, such as THC, and review studies demonstrating that THC-induced impairments in decision-making processes are mediated by actions at prefrontal CB1 receptors. We further describe evidence that signalling through prefrontal or ventral hippocampal CB1 receptors modulates mesolimbic dopamine activity, aberrations of which may contribute to emotional processing deficits in schizophrenia. Lastly, we review studies suggesting that endocannabinoid tone in the amygdala is a critical regulator of anxiety, and report new data showing that FAAH activity is integral to this response. Together, these findings underscore the importance of cannabinoid signalling in the regulation of cognitive and affective behaviours, and encourage further research given their social, political, and therapeutic implications. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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