Spatial localization of retinal anomalies in regular cannabis users: The relevance of the multifocal electroretinogram

SCHIZOPHRENIA RESEARCH

卷:219

Article

Schwitzer, Thomas^1,2  Henrion, Marie-Laure¹  Sarre, Daphne¹  Albuisson, Eliane^5,6,7  Angioi-Duprez, Karine⁴  Giersch, Anne²  Lalanne, Laurence⁸  Schwan, Raymund^1,2,3  Laprevote, Vincent^1,2 

[1] Pole Hosp Univ Psychiat Adultes Grand Nancy, Ctr Psychotherap Nancy, Laxou, France

[2] Ctr Hosp Reg Univ Strasbourg, Dept Psychiat, Federat Med Translat Strasbourg, INSERM U1114, Strasbourg, France

[3] CHRU Nancy, Maison Addict, Nancy, France

[4] CHRU Nancy, Serv Ophtalmol, Nancy, France

[5] CHRU Nancy, BIOBASE, PARC, Pole S2R, Vandoeuvre Les Nancy, France

[6] Univ Lorraine, Fac Med, InSciDens, Vandoeuvre Les Nancy, France

[7] CNRS, Inst Elie Carton Lorraine, UMR 7502, F-54506 Vandoeuvre Les Nancy, France

[8] Univ Hosp Strasbourg, Dept Addictol, FMTS Federat Med Translat, INSERM 1114, Strasbourg, France

关键词: Cannabis;    Endocannabinoid system;    Retina;    Retinal information processing;    Multifocal electroretinogram;    Synaptic transmission;   

DOI  :  10.1016/j.schres.2019.01.013

来源: Elsevier

【 摘 要 】

Widely used in industrialized countries, cannabis is a neuromodulator substance. The cannabinoid system is present at critical stages of retinal processing. We have recently shown a delay in bipolar and ganglion cell responses in reg- ular cannabis users, as observed using flash (fERG) and pattern (PERG) electroretinogram. Although the results ob- tained during these tests provide information about global retinal responses, they do not give any indication about the spatial localization of the anomalies that were detected. The latter may be analyzed, however, by means of mul- tifocal electroretinogram (mfERG). We recorded the mfERG responses in 49 regular cannabis users and 21 healthy subjects. The amplitudes and implicit times of the mfERG N1, P1 and N2 waves were recorded. The results showed that in regular cannabis users: in the b2? region, a signi ficant increase in the N2 implicit time (p = 0.037); in the 2-5? region, a signi ficant increase in the N2 (p = 0.018) and P1 (p = 0.046) implicit times; in the 5-10? region, a signi ficant increase in the P1 (p = 0.006) and N1 (p = 0.034) implicit times; and in the 10-15? region, a signi ficant increase in the P1 implicit time (p = 0.014). An isolated decrease in the N1 amplitude in the 2-5? region (p = 0.044) was also found. This indicates that there is a delay in the transmission of visual information from the central retina to the near periphery in cannabis users suggesting potential alterations in precise and color vision.

【 授权许可】

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