Central fatigue theory and endurance exercise: Toward an interoceptive model

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:93

Review

McMorris, Terry^1,2,3  Barwood, Martin⁴  Corbett, Jo¹ 

[1] Univ Portsmouth, Fac Sci, Dept Sport & Exercise Sci, Portsmouth PO1 2ER, Hants, England

[2] Univ Chichester, Inst Sport, Dept Sport & Exercise Sci, Coll Lane, Chichester PO19 6PE, W Sussex, England

[3] Northumbria Univ, Dept Psychol, Fac Hlth & Life Sci, 10 Northumberland Rd, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[4] Leeds Trinity Univ, Dept Sport Hlth & Nutr, Brownberrie Lane 12, Horsforth LS18 5HD, England

关键词: 5-hyclroxytryptamine;    Insula cortex;    Anterior cingulate cortex;    Dorsolateral prefrontal cortex;    Ventrolateral prefrontal cortex;    Ventromedial prefrontal cortex;    Substantia nigra pars compacta;    Ventral tegmental area;    Locus coeruleus;    Dopamine;    Norepinephrine;    Motivation;   

DOI  :  10.1016/j.neubiorev.2018.03.024

来源: Elsevier

【 摘 要 】

We propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina I lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, which is forwarded to the anterior cingulate cortex (ACC), ventromedial (VM)PFC and lateral (L)PFC. The LPFC integrates the information and makes a decision as to whether to continue or stop. The decision is dependent upon interaction with the substantia nigra pars compacta and ventral tegrnental area dopamine (DA), and locus coeruleus (LC)-norepinephrine (NE) systems. Phasic activation of DA and NE neurons appears to be necessary for maintenance of goal-related action but the VMPFC and ACC, which project to the LC, induce tonic NE activity when the rewards are thought to be not worth the cost thus fatigue is perceived.

【 授权许可】

Free