Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:106

Review

Sampedro-Piquero, Patricia¹  Ladron de Guevara-Miranda, David¹  Pavon, Francisco J.²  Serrano, Antonia²  Suarez, Juan²  Rodriguez de Fonseca, Fernando²  Santin, Luis J.¹  Castilla-Ortega, Estela² 

[1] Univ Malaga, Fac Psicol, Inst Invest Biomed Malaga IBIMA, Dept Psicobiol & Metodol Ciencias Comportamiento, Malaga, Spain

[2] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Ave Carlos Haya 82, Malaga 29010, Spain

关键词: Neuroplasticity;    Environmental enrichment;    Cognitive training;    Exercise;    Memory;    Executive function;   

DOI  :  10.1016/j.neubiorev.2018.11.015

来源: Elsevier

【 摘 要 】

Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal-directed behaviors become corrupted, which may lead to cognitive deficits that coexist with other addiction symptoms and predict a worse treatment outcome. New learning experiences that are not motivated by drugs may improve both cognitive deficits and druginduced symptoms by promoting adaptive neuroplastic changes that could alleviate or reverse those involved in addiction. The present review will focus on whether potentiating healthy cognitive function, either by formal cognitive training or non-drug related environmental experiences, could exert beneficial effects in the therapeutics of addiction. Although additional studies are needed, the available clinical and preclinical evidence suggests that cognitive stimulation may provide a valuable adjuvant intervention in drug addiction.

【 授权许可】

Free