A dimensional approach to functional movement disorders: Heresy or opportunity

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:127

Article

Spagnolo, Primavera A.^1,3  Garvey, Marjorie²  Hallett, Mark³ 

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Mary Horrigan Connors Ctr Womens Hlth & Gender Bi, Boston, MA 02115 USA

[2] NIH, Novel Strategies Treatment Dev Psychopathol Progr, Biomarker & Intervent Dev Childhood Onset Mental, NIMH, Bldg 10, Bethesda, MD 20892 USA

[3] NIH, Human Motor Control Sect, Med Neurol Branch, NINDS, Bldg 10,Room 7D37,10 Ctr Dr, Bethesda, MD 20892 USA

关键词: Functional movement disorders;    Research domain criteria;    Neurocircuitry;    Neuroimaging;    Mechanisms;    Brain-behavior dimensions;   

DOI  :  10.1016/j.neubiorev.2021.04.005

来源: Elsevier

【 摘 要 】

Functional movement disorders (FMD) are a common and disabling neuropsychiatric condition, part of the spectrum of functional neurological/conversion disorder. FMD represent one of the most enigmatic disorders in the history of medicine. However, in the twenty years after the first report of distinctive abnormal brain activity associated with functional motor symptoms, there have been tremendous advances in the pathophysiologic understanding of these disorders. FMD can be characterized as a disorder of aberrant neurocircuitry interacting with environmental and genetic factors. These developments suggest that research on FMD could be better served by an integrative, neurosciencebased approach focused on functional domains and their neurobiological substrates. This approach has been developed in 'Research Domain Criteria' (RDoC) project, which promotes a dimensional approach to psychiatric disorders. Here, we use the RDoC conceptualization to review recent neuroscience research on FMD, focusing on the domains most relevant to these disorders. We discuss how the adoption of a similar integrative framework may facilitate the identification of the mechanisms underlying FMD and could also have potential clinical applicability.

【 授权许可】

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