Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:130

Article

Trask, Sydney¹  Ferrara, Nicole C.²  Jasnow, Aaron M.³  Kwapis, Janine L.⁴ 

[1] Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA

[2] Rosalind Franklin Univ Med & Sci, Dept Pharmacol, N Chicago, IL 60064 USA

[3] Univ South Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29209 USA

[4] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

关键词: Anterior cingulate;    Retrosplenial;    Learning;    Memory;    Recent;    Remote;   

DOI  :  10.1016/j.neubiorev.2021.08.023

来源: Elsevier

【 摘 要 】

While the anterior cingulate (ACC) and retrosplenial (RSC) cortices have been extensively studied for their role in spatial navigation, less is known about how they contribute to associative learning and later memory recall. The limited work that has been conducted on this topic suggests that each of these cortical regions makes distinct, but similar contributions to associative learning and memory. Here, we review evidence from the rodent literature demonstrating that while ACC activity seems to be necessary at remote time points associated with imprecise or generalized memories, the role of the RSC seems to be uniform over time. Together, the lines of evidence reviewed here suggest that the ACC and RSC likely function together to support memory formation and maintenance following associative learning.

【 授权许可】

Free