Lateral septum as a nexus for mood, motivation, and movement

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:126

Review

Wirtshafter, Hannah S.^1,2  Wilson, Matthew A.^1,2,3 

[1] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Picower Inst Learning & Memory, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA

关键词: Reward;    Motivation;    Movement;    Navigation;    Anxiety;    Planning;    Place cells;    Hippocampus;    Septum;   

DOI  :  10.1016/j.neubiorev.2021.03.029

来源: Elsevier

【 摘 要 】

The lateral septum (LS) has been implicated in a wide variety of functions, including emotional, motivational, and spatial behavior, and the LS may regulate interactions between the hippocampus and other regions that mediate goal directed behavior. In this review, we suggest that the lateral septum incorporates movement into the evaluation of environmental context with respect to motivation, anxiety, and reward to output an 'integrated movement value signal'. Specifically, hippocampally-derived contextual information may be combined with reinforcement or motivational information in the LS to inform task-relevant decisions. We will discuss how movement is represented in the LS and the literature on the LS's involvement in mood and motivation. We will then connect these results to LS movement-related literature and hypotheses about the role of the lateral septum. We suggest that the LS may communicate a movement-scaled reward signal via changes in place-, movement-, and reward-related firing, and that the LS should be considered a fundamental node of affect and locomotor pathways in the brain.

【 授权许可】

Free