Evaluating rodent motor functions: Which tests to choose?

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:83

Review

Schoenfeld, Lisa-Maria¹  Dooley, Dearbhaile²  Jahanshahi, Ali³  Temel, Yasin^3,4  Hendrix, Sven⁵ 

[1] Heinrich Heine Univ Disseldof, Comparat Psychol, Inst Expt Psychol, Dusseldorf, Germany

[2] Univ Coll Dublin, Sch Med, Hlth Sci Ctr, Dublin, Ireland

[3] Maastricht Univ, Dept Neurosci, Maastricht, Netherlands

[4] Maastricht Univ, Dept Neurosurg, Med Ctr, Maastricht, Netherlands

[5] Hasselt Univ, Dept Morphol, Biomed Res Inst BIOMED, Hasselt, Belgium

关键词: Motor tests;    Rodents;    Stroke;    TBI;   

DOI  :  10.1016/j.neubiorev.2017.10.021

来源: Elsevier

【 摘 要 】

Damage to the motor cortex induced by stroke or traumatic brain injury (TBI) can result in chronic motor deficits. For the development and improvement of therapies, animal models which possess symptoms comparable to the clinical population are used. However, the use of experimental animals raises valid ethical and methodological concerns. To decrease discomfort by experimental procedures and to increase the quality of results, non-invasive and sensitive rodent motor tests are needed. A broad variety of rodent motor tests are available to determine deficits after stroke or TBI. The current review describes and evaluates motor tests that fall into three categories: Tests to evaluate fine motor skills and grip strength, tests for gait and inter-limb coordination and neurological deficit scores. In this review, we share our thoughts on standardized data presentation to increase data comparability between studies. We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line.

【 授权许可】

Free