A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:121

Review

Williams, Zachary J.^1,2,3,4  He, Jason L.⁵  Cascio, Carissa J.^3,4,6,7  Woynaroski, Tiffany G.^2,3,4,7 

[1] Vanderbilt Univ, Sch Med, Med Scientist Training Program, 221 Eskind Biomed Lib & Learning Ctr, Nashville, TN 37240 USA

[2] Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, 1215 21st Ave South,Med Ctr East,Room 8310, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Vanderbilt Brain Inst, 7203 Med Res Bldg 3,465 21st Ave South, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Frist Ctr Autism & Innovat, 2414 Highland Ave,Suite 115, Nashville, TN 37212 USA

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sackler Inst Translat Neurodev, Dept Forens & Neurodev Sci, Strand Bldg,Strand Campus, London WC2R 2LS, England

[6] Vanderbilt Univ, Med Ctr, Dept Psychiat & Behav Sci, 2254 Village Vanderbilt,1500 21st Ave South, Nashville, TN 37212 USA

[7] Vanderbilt Univ, Med Ctr, Vanderbilt Kennedy Ctr, 110 Magnolia Cir, Nashville, TN 37203 USA

关键词: Autism spectrum disorder;    Auditory;    Sensory;    Decreased sound tolerance;    Sensitivity;    Hyperacusis;    Misophonia;    Phonophobia;    Central gain;    Salience;    Anxiety;    Specific phobia;    Review;    Theory;   

DOI  :  10.1016/j.neubiorev.2020.11.030

来源: Elsevier

【 摘 要 】

Atypical behavioral responses to environmental sounds are common in autistic children and adults, with 50-70 % of this population exhibiting decreased sound tolerance (DST) at some point in their lives. This symptom is a source of significant distress and impairment across the lifespan, contributing to anxiety, challenging behaviors, reduced community participation, and school/workplace difficulties. However, relatively little is known about its phenomenology or neurocognitive underpinnings. The present article synthesizes a large body of literature on the phenomenology and pathophysiology of DST-related conditions to generate a comprehensive theoretical account of DST in autism. Notably, we argue against conceptualizing DST as a unified construct, suggesting that it be separated into three phenomenologically distinct conditions: hyperacusis (the perception of everyday sounds as excessively loud or painful), misophonia (an acquired aversive reaction to specific sounds), and phonophobia (a specific phobia of sound), each responsible for a portion of observed DST behaviors. We further elaborate our framework by proposing preliminary neurocognitive models of hyperacusis, misophonia, and phonophobia that incorporate neurophysiologic findings from studies of autism.

【 授权许可】

Free