Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:130

Review

Faillot, Matthieu^1,3  Chaillet, Antoine²  Palfi, Stephane¹  Senova, Suhan¹ 

[1] Univ Paris Est Creteil, Mondor Inst Biomed Res, Translat Neuropsychiat,DMU CARE,INSERM,Team 15, Henri Mondor Univ Hosp,AP HP,Neurosurg Dept,U955, Creteil, France

[2] Univ Paris Saclay, Inst Univ France, Lab Signaux & Syst L2S, UMR8506,Cent Supelec, Paris, France

[3] Beaujon Univ Hosp, AP HP, Neurosurg Dept, Clichy, France

关键词: Traumatic Brain Injury;    Stroke;    Rodent;    Deep Brain Stimulation;    Memory;   

DOI  :  10.1016/j.neubiorev.2021.08.012

来源: Elsevier

【 摘 要 】

Deep brain stimulation paradigms might be used to treat memory disorders in patients with stroke or traumatic brain injury. However, proof of concept studies in animal models are needed before clinical translation. We propose here a comprehensive review of rodent models for Traumatic Brain Injury and Stroke. We systematically review the histological, behavioral and electrophysiological features of each model and identify those that are the most relevant for translational research.

【 授权许可】

Free