Association between suicidal spectrum behaviors and Attention-Deficit/Hyperactivity Disorder: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:103

Review

Septier, Mathilde^1,2  Stordeur, Coline¹  Zhang, Junhua³  Delorme, Richard^1,4  Cortese, Samuele^5,6,7,8,9 

[1] Robert Debre Hosp, Dept Child & Adolescent Psychiat, F-75019 Paris, France

[2] Ctr Psychiat & Neurosci, INSERM, Team 1, U894, Paris, France

[3] Yancheng Teachers Univ, Sch Educ, Jiangsu Key Lab Big Data Psychol & Cognit Sci, Yancheng 224002, Peoples R China

[4] Inst Pasteur, Human Genet & Cognit Funct, Paris, France

[5] Univ Southampton, Ctr Innovat Mental Hlth, Acad Unit Psychol, Southampton SO17 1BJ, Hants, England

[6] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton SO17 1BJ, Hants, England

[7] Solent NHS Trust, Southampton SO19 8BR, Hants, England

[8] NYU, Ctr Child Study, 550 1St Ave, New York, NY 10016 USA

[9] Univ Nottingham, Sch Med, Div Psychiat & Appl Psychol, Nottingham NG7 2UH, England

关键词: ADHD;    Suicide;    Children;    Adults;   

DOI  :  10.1016/j.neubiorev.2019.05.022

来源: Elsevier

【 摘 要 】

The relationship between ADHD and suicidal spectrum behaviors (SSBs) remains uncertain. We conducted the first meta-analysis on the association between ADHD and SSBs taking possible confounders into account. Based on a pre-registered protocol (PROSPERO-CRD42018093003), we searched Pubmed, Ovid and Web of Knowledge databases through April 6th, 2018, with no language/publication type restrictions, and contacted study authors for unpublished data/information. From a pool of 2798 references, we retained 57 studies. Random-effects models were performed. Study quality was rated using the Newcastle-Ottawa Scale. After pooling crude ORs, we found a significant association between ADHD and suicidal attempts (2.37, 95% CI = 1.64-3.43; I-2 = 98.21), suicidal ideations (3.53, 2.94-4.25; I-2 = 73.73), suicidal plans (4.54, 2.46-8.37; I-2 = 0), and completed suicide (6.69, 3.24-17.39; I-2 = 87.53). Results did not substantially change when pooling adjusted ORs. Findings were also in general robust to sensitivity analyses to assess possible moderators. Awareness of the association between ADHD and SSBs should contribute to more effectively prevent SSBs.

【 授权许可】

Free