Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:107

Review

Haaker, Jan¹  Maren, Stephen^2,3  Marta, Andreatta^4,12  Merz, Christian J.⁵  Richter, Jan⁶  Helene, Richter S.⁷  Shira, Meir Drexler⁵  Lange, Maren D.⁸  Kay Jungling⁸  Nees, Frauke⁹  Seidenbecher, Thomas⁸  Fullana, Miquel A.¹⁰  Carsten, Wotjak T.¹¹  Lonsdorf, Tina B.¹ 

[1] Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, Hamburg, Germany

[2] Texas A&M Univ, Dept Psychol & Brain Sci, College Stn, TX 77843 USA

[3] Texas A&M Univ, Inst Neurosci, College Stn, TX 77843 USA

[4] Univ Wurzburg, Dept Psychol, Wurzburg, Germany

[5] Ruhr Univ Bochum, Fac Psychol, Inst Cognit Neurosci, Dept Cognit Psychol, Bochum, Germany

[6] Ernst Moritz Arndt Univ Greifswald, Dept Biol & Clin Psychol Psychotherapy, Greifswald, Germany

[7] Univ Munster, Dept Behav Biol, Munster, Germany

[8] Univ Munster, Inst Physiol 1, Munster, Germany

[9] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[10] Hosp Clin Barcelona, Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Neurosci, Barcelona, Spain

[11] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Neuronal Plast Res Grp, D-80804 Munich, Germany

[12] Erasmus Univ, Dept Psychol Educ & Child Studies, Rotterdam, Netherlands

关键词: Fear conditioning;    Fear extinction;    Associative learning;    Rodent;    Human;    Translation;    Meta-research;    Startle;    FPS;    SCR;    Treezing;    Heat-rate;    Paradigm;    Methods;    Individual differences;   

DOI  :  10.1016/j.neubiorev.2019.09.020

来源: Elsevier

【 摘 要 】

Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.

【 授权许可】

Free