The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:35

Review

Young, Kimberly A.¹ 

[1] Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA

关键词: Maternal behavior;    Social play;    Pair bonding;    Aggression;    Sexual behavior;    Drug addiction;    Psychostimulants;    Cocaine;    Amphetamine;    Opiates;    Morphine;    Alcohol;    Mesolimbic;    Dopamine;    Nucleus accumbens;    Prefrontal cortex;    Ventral tegmental area;   

DOI  :  10.1016/j.neubiorev.2010.06.004

来源: Elsevier

【 摘 要 】

The use of addictive drugs can have profound short- and long-term consequences on social behaviors. Similarly, social experiences and the presence or absence of social attachments during early development and throughout life can greatly influence drug intake and the susceptibility to drug abuse. The following review details this reciprocal interaction, focusing on common drugs of abuse (e.g., psychostimulants, opiates, alcohol and nicotine) and social behaviors (e.g., maternal, sexual, play, aggressive and bonding behaviors). The neural mechanisms underlying this interaction are discussed, with a particular emphasis on the involvement of the mesocorticolimbic dopamine system. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free