Development of auditory cortical synaptic receptive fields

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:35

Review

Froemke, Robert C.¹ 

[1] NYU, Skirball Inst Biomol Med, Helen & Martin Kimmel Ctr Biol & Med, Mol Neurobiol Program,Sch Med,Dept Otolaryngol, New York, NY 10016 USA

关键词: Auditory cortex;    Development;    Excitatory-inhibitory balance;    Plasticity;    Receptive fields;   

DOI  :  10.1016/j.neubiorev.2011.02.006

来源: Elsevier

【 摘 要 】

The central nervous system is plastic throughout life, but is most sensitive to the statistics of the sensory environment during critical periods of early postnatal development. In the auditory cortex, various forms of acoustic experience have been found to shape the formation of receptive fields and influence the overall rate of cortical organization. The synaptic mechanisms that control cortical receptive field plasticity are beginning to be described, particularly for frequency tuning in rodent primary auditory cortex. Inhibitory circuitry plays a major role in critical period regulation, and new evidence suggests that the formation of excitatory-inhibitory balance determines the duration of critical period plasticity for auditory cortical frequency tuning. Cortical inhibition is poorly tuned in the infant brain, but becomes co-tuned with excitation in an experience-dependent manner over the first postnatal month. We discuss evidence suggesting that this may be a general feature of the developing cortex, and describe the functional implications of such transient excitatory-inhibitory imbalance. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free