The neural circuitry supporting successful spatial navigation despite variable movement speeds

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Review

Sheeran, William M.^1,6,7  Ahmed, Omar J.^2,3,4,5 

[1] Univ Michigan, Dept Psychol, 580 Union Dr, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Neurosci Grad Program, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[7] Univ Colorado, Sch Med, Med Scientist Training Program, Aurora, CO 80045 USA

关键词: Running speed;    Spatial navigation;    Learning & memory;    Brain rhythms;    Neural coding;    Temporal code;    Rate code;    Hippocampus;    Entorhinal cortex;    Secondary motor cortex;    Medial septum;    Mesencephalic locomotor region;   

DOI  :  10.1016/j.neubiorev.2019.11.013

来源: Elsevier

【 摘 要 】

Ants who have successfully navigated the long distance between their foraging spot and their nest dozens of times will drastically overshoot their destination if the size of their legs is doubled by the addition of stilts. This observation reflects a navigational strategy called path integration, a strategy also utilized by mammals. Path integration necessitates that animals keep track of their movement speed and use it to precisely and instantly modify where they think they are and where they want to go. Here we review the neural circuitry that has evolved to integrate speed and space. We start with the rate and temporal codes for speed in the hippocampus and work backwards towards the motor and sensory systems. We highlight the need for experiments designed to differentiate the respective contributions of motor efference copy versus sensory inputs. In particular, we discuss the importance of high-resolution tracking of the latency of speed-encoding as a precise way to disentangle the sensory versus motor computations that enable successful spatial navigation at very different speeds.

【 授权许可】

Free