Acute neural effects of selective serotonin reuptake inhibitors versus noradrenaline reuptake inhibitors on emotion processing: Implications for differential treatment efficacy

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:37

Review

Outhred, Tim^1,2  Hawkshead, Brittany E.³  Wager, Tor D.⁴  Das, Pritha^1,5,6  Malhi, Gin S.^1,5,6  Kemp, Andrew H.^1,2,5,6,7 

[1] Univ Sydney, Royal N Shore Hosp, Sydney Med Sch, Discipline Psychiat, St Leonards, NSW 2065, Australia

[2] Univ Sydney, Sch Psychol, SCAN Res & Teaching Unit, Sydney, NSW 2006, Australia

[3] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA

[4] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[5] Royal N Shore Hosp, Dept Psychiat, CADE Clin, St Leonards, NSW 2065, Australia

[6] Univ Sydney, Royal N Shore Hosp, St Leonards, NSW 2065, Australia

[7] Univ Sao Paulo, Univ Hosp, BR-05508000 Sao Paulo, Brazil

关键词: Antidepressants;    SSRI;    NRI;    Serotonin;    Noradrenalin;    Emotion;    fMRI;    Multi-Level Kernel Density Analysis Meta-analysis;   

DOI  :  10.1016/j.neubiorev.2013.07.010

来源: Elsevier

【 摘 要 】

Clinical research has demonstrated differential efficacy of selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), which may relate to differential acute effects these medications have on emotional brain processes. Here we present findings from a Multi-Level Kernel Density Analysis meta-analysis that integrates and contrasts activations from disparate fMRI studies in order to examine whether single dose SSRIs and NRIs have different effects on emotion processing tasks in healthy participants. Seven SSRI and four NRI studies were eligible for inclusion. SSRIs decreased amygdala responses, suggesting reduced emotional reactivity to emotional stimuli, whereas NRIs increased frontal and medial activation, suggesting increased emotion regulation. As hypothesised, an interaction of antidepressant and task type was found, such that SSRIs modulated amygdaloid-hippocampal, medial and frontal activity during both the presentation of faces and pictures, whereas NRIs only modulated the activation in medial and frontal regions during the presentation of pictures. Findings are interpreted within a novel model of the differential effects of SSRIs and NRIs on emotion processing. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free