Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:90

Review

Puiu, Andrei A.¹  Wudarczyk, Olga^2,10  Goerlich, Katharina S.^2,8,10  Votinov, Mikhail^2,3,4,5,10  Herpertz-Dahlmann, Beate^7,9  Turetsky, Bruce^6,11  Konrad, Kerstin^1,9 

[1] Rhein Westfal TH Aachen, Med Fac, Dept Child & Adolescent Psychiat Psychosomat & Ps, Child Neuropsychol Sect, Aachen, Germany

[2] Rhein Westfal TH Aachen, Med Fac, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[3] Res Ctr Julich, JARA Inst Brain Struct Funct Relationship, Pauwelsstr 30, D-52074 Aachen, Germany

[4] Rhein Westfal TH Aachen, Pauwelsstr 30, D-52074 Aachen, Germany

[5] Res Ctr Julich, Inst Neurosci & Med 10, Aachen, Germany

[6] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[7] Rhein Westfal TH Aachen, Med Fac, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Groningen, Netherlands

[9] Rhein Westfal TH Aachen, Med Fac, Dept Child & Adolescent Psychiat Psychosomat & Ps, Neunhofer Weg 21, D-52074 Aachen, Germany

[10] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, D-52074 Aachen, Germany

[11] Univ Penn, Dept Psychiat, 3400 Spruce St,10th Floor, Philadelphia, PA 19104 USA

关键词: Impulsive aggression;    Response inhibition;    ADHD;    DBDs;    fMRI;    sMRI;    Prefrontal cortex;    Cingulate cortex;    Paralimbic system;    Control;    Top-Down;    Emotional salience;   

DOI  :  10.1016/j.neubiorev.2018.04.016

来源: Elsevier

【 摘 要 】

Background: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. Aims and Methods: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder -specific and shared IA and RI aberrant neural mechanisms. Results: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity. Conclusion: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.

【 授权许可】

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