Aberrant brain activation of error processing among adults with attention deficit and hyperactivity disorder

Kaohsiung Journal of Medical Sciences

Chiao-Yun Chen¹  Gin-Chung Liu¹  Chih-Yuan Liang²  Ju-Yu Yen²  Cheng-Sheng Chen²  Chih-Hung Ko²  Cheng-Fang Yen² 

[1] Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;

关键词: ADHD;    Error processing;    Inferior frontal lobe;    Insula;    Response inhibition;   

DOI  :  10.1016/j.kjms.2015.01.001

来源: DOAJ

【 摘 要 】

Individuals with adult attention deficit/hyperactivity disorder (ADHD) have a deficit in their cognitive control. The aim of this study was to reveal the brain correlates of the deficits in response inhibition or error processing in adult ADHD. A total of 29 adults with ADHD and 25 control individuals were recruited. They completed an event-related-design Go/No-go task under functional magnetic resonance imaging scanning. Both the ADHD group and the control group exhibited activation of the frontostriatal network when processing response inhibition. They also exhibited activation of the frontoinsula cortex and anterior cingulate in error processing. Adults with ADHD have a lower brain activation of error processing over the right inferior frontal lobe adjacent to the insula than control individuals. The altered frontoinsula cortex activation may represent the mechanism of error processing deficit among adults with ADHD.

【 授权许可】

Unknown