Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:84

Review

Samuelsson, Laura B.¹  Bovbjerg, Dana H.^1,2,3,4  Roecklein, Kathryn A.^1,5  Hall, Martica H.^1,2 

[1] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Behav & Community Hlth Sci, Pittsburgh, PA USA

[4] Univ Pittsburgh, Canc Inst, Biobehav Oncol Program, Pittsburgh, PA USA

[5] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA USA

关键词: Breast cancer;    Circadian disruption;    Sleep disruption;    Sleep;    Sleep duration;    Light at night;    Night shift work;    LAN;    Mammary oncogenesis;    Circadian rhythms;    Cancer;   

DOI  :  10.1016/j.neubiorev.2017.10.011

来源: Elsevier

【 摘 要 】

Opportunities for restorative sleep and optimal sleep-wake schedules are becoming luxuries in industrialized cultures, yet accumulating research has revealed multiple adverse health effects of disruptions in sleep and circadian rhythms, including increased risk of breast cancer. The literature on breast cancer risk has focused largely on adverse effects of night shift work and exposure to light at night (LAN), without considering potential effects of associated sleep disruptions. As it stands, studies on breast cancer risk have not considered the impact of both sleep and circadian disruption, and the possible interaction of the two through bidirectional pathways, on breast cancer risk in the population at large. We review and synthesize this literature, including: 1) studies of circadian disruption and incident breast cancer; 2) evidence for bidirectional interactions between sleep and circadian systems; 3) studies of sleep and incident breast cancer; and 4) potential mechanistic pathways by which interrelated sleep and circadian disruption may contribute to the etiology of breast cancer.

【 授权许可】

Free