Stress-induced plasticity and functioning of ventral tegmental dopamine neurons

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Article

Douma, Erik H.¹  de Kloet, E. Ronald² 

[1] Univ Amsterdam, Swammerdam Inst Life Sci, Room C3-102,Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

[2] Leiden Univ, Dept Endocrinol, Med Ctr, Leiden, Netherlands

关键词: Ventral tegmental area;    Mesocorticolimbic system;    Dopamine;    Stress;    Glucocorticoids;    CRH;    Opioids;    BDNF;    Depression;    Addiction;    Neurodegeneration;    Cognition;    Habituation;    Coping;    Adaptation;    Microglia;   

DOI  :  10.1016/j.neubiorev.2019.10.015

来源: Elsevier

【 摘 要 】

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional, motivational, and social reward associations together with their more demanding cognitive aspects that involve the mesocortical circuitry. Coping with stress increases VTA-DA excitability, but when the stressor becomes chronic the VTA-DA circuit is less active, which may lead to degeneration and local microglial activation. This switch between activation and inhibition of VTA-DA neurons is modulated by e.g. corticotropin-releasing hormone (CRH), opioids, brain-derived neurotrophic factor (BDNF), and the adrenal glucocorticoids. These actions are coordinated with energy-demanding stress-coping styles to promote behavioral adaptation. The VTA circuits show sexual dimorphism that is programmed by sex hormones during perinatal life in a manner that can be affected by glucocorticoid exposure. We conclude that insight in the role of stress in VTA-DA plasticity and connectivity, during reward processing and stress-coping, will be helpful to better understand the mechanism of resilience to breakdown of adaptation.

【 授权许可】

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