Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:117

Review

Desplats, Paula^1,2  Gutierrez, Ashley M.¹  Antonelli, Marta C.^3,4  Frasch, Martin G.^5,6 

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[3] Univ Buenos Aires, Inst Biol Celular & Neurociencia Prof Eduardo De, Fac Med, Buenos Aires, DF, Argentina

[4] Tech Univ Munich, Dept Obstet & Gynecol, Klinikum Rechts Isar, Munich, Germany

[5] Univ Washington, Dept Obstet & Gynecol, 1959 NE Pacific St,Box 356460, Seattle, WA 98195 USA

[6] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA

关键词: Pregnancy stress;    Neuroinflammation;    Early life;    Glia;    Alzheimer's;    Parkinson's;    CHRNA7;    Enriched environment;    Policy;    Animal models;   

DOI  :  10.1016/j.neubiorev.2019.10.013

来源: Elsevier

【 摘 要 】

We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?

【 授权许可】

Free