The impact of chronic stress during adolescence on the development of aggressive behavior: A systematic review on the role of the dopaminergic system in rodents

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:91

Review

Tielbeek, Jorim J.^1,2  Al-Itejawi, Zeineb¹  Zijlmans, Josjan¹  Polderman, Tinca J. C.^2,3  Buckholtz, Joshua W.^4,5,6  Popma, Arne^1,7 

[1] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Child & Adolescent Psychiat, Duivendrecht, Netherlands

[2] Vrije Univ Amsterdam, CNCR, Dept Complex Trait Genet, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Clin Genet, Sect Complex Trait Genet, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[4] Harvard Univ, Dept Psychol, 52 Oxford St, Cambridge, MA 02138 USA

[5] Harvard Univ, Ctr Brain Sci, 52 Oxford St, Cambridge, MA 02138 USA

[6] Massachusetts Gen Hosp, Dept Psychiat, 55 Fruit St, Boston, MA 02114 USA

[7] Leiden Univ, Inst Criminal Law & Criminol, Fac Law, Leiden, Netherlands

关键词: Adverse environment;    Maladaptive behavior;    Mesolimbic;    Mesocortical;    Antisocial;    Peri-adolescent stress;   

DOI  :  10.1016/j.neubiorev.2016.10.009

来源: Elsevier

【 摘 要 】

Pathological aggression, frequently observed in psychiatric patients and criminal subjects, poses a major burden on the health care and criminal justice system, necessitating better aetiological models to inform targets for prevention and intervention. Emerging evidence suggests that adverse experiences during development can cause long-lasting brain alterations associated with maladaptive behaviors, such as aggression. The present review discusses, mainly based on studies in rodents, whether disruption of the mesocorticolimbic dopamine system through chronic stress-exposure during adolescence predisposes to adult aggression. Our findings suggest that chronic stress in adolescence induces prefrontal cortex (PFC) hyperdopaminergia and ultimately leads to blunted prefrontal dopamine transmission in adulthood. This, in turn, disrupts the ability of the PFC to guide adaptive, long-term focused action selection by regulating mesolimbic dopamine signaling. We propose that, especially during the dynamic and transitional period of adolescence, exposure to chronic stress could lead to excessive adaptive change, which may result in an increased vulnerability to maladaptive aggression in adulthood. We discuss how these findings in rodents may translate to humans. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free