Reward and aversion in a heterogeneous midbrain dopamine system

NEUROPHARMACOLOGY

卷:76

Review

Lammel, Stephan¹  Lim, Byung Kook¹  Malenka, Robert C.¹ 

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA

关键词: Dopamine;    Reward;    Aversion;    Mesocortical;    Mesolimbic;    Ventral tegmental area;   

DOI  :  10.1016/j.neuropharm.2013.03.019

来源: Elsevier

【 摘 要 】

The ventral tegmental area (VIA) is a heterogeneous brain structure that serves a central role in motivation and reward processing. Abnormalities in the function of VTA dopamine (DA) neurons and the targets they influence are implicated in several prominent neuropsychiatric disorders including addiction and depression. Recent studies suggest that the midbrain DA system is composed of anatomically and functionally heterogeneous DA subpopulations with different axonal projections. These findings may explain a number of previously confusing observations that suggested a role for DA in processing both rewarding as well as aversive events. Here we will focus on recent advances in understanding the neural circuits mediating reward and aversion in the VIA and how stress as well as drugs of abuse, in particular cocaine, alter circuit function within a heterogeneous midbrain DA system. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free