Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:108

Review

Kluwe-Schiavon, B.^1,2  Viola, T. W.²  Sanvicente-Vieira, B.²  Lumertz, F. S.²  Salum, G. A.³  Grassi-Oliveira, R.²  Quednow, B. B.^1,4,5 

[1] Univ Zurich, Expt & Clin Pharmacopsychol, Dept Psychiat Psychotherapy & Psychosomat, Psychiat Hosp, Lenggstr 31, CH-8032 Zurich, Switzerland

[2] Pontificia Univ Catolica Rio Grande do Sul, Dev Cognit Neurosci Lab, Brain Inst, Ipiranga Ave 6681,11,936, BR-90619900 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Hosp Clinicas Porto Alegre, Ramiro Barcelos St 2350, BR-90035007 Porto Alegre, RS, Brazil

[4] Univ Zurich, Neurosci Ctr Zurich, Ramistr 101, CH-8092 Zurich, Switzerland

[5] Swiss Fed Inst Technol Zurich, Ramistr 101, CH-8092 Zurich, Switzerland

关键词: Addiction;    Decision-making;    Substance use related disorders;    Cognition;    Impulsivity;    Temporal discounting;    Risk-taking;    Impulse control;    Reward impulsivity;   

DOI  :  10.1016/j.neubiorev.2019.11.016

来源: Elsevier

【 摘 要 】

Across numerous studies, individuals with substance use disorders (SUDs) differed from non-using controls regarding valuation of delayed gratification and feedback processing. However, it remains unclear whether the magnitude of the effect sizes is different across these two cognitive processes and how specific SUDs as well as demographic and clinical moderators influence these effects. In this study we thus performed multilevel linear mixed-effects meta-analyses and meta-regressions to examine the effects of SUDs on the Delay Discounting Task (DD) and on the Iowa Gambling Task (IGT). We found a moderate to large effect for SUD on both, the IGT and DD. While the effect on the DD was generalized to all substance classes, a smaller effect for cannabis-related disorder when compared to other SUDs was found with regard to the IGT. Early onset of substance use and psychiatric comorbidities were associated with stronger effects on the DD. Our findings suggest that feedback processing is more vulnerable to specific substance effects, while valuation of delayed gratification depends more on developmental and clinical factors.

【 授权许可】

Free