The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:130

Article

Huibregtse, Megan E.¹  Bazarian, Jeffrey J.²  Shultz, Sandy R.^3,4  Kawata, Keisuke^1,5 

[1] Indiana Univ, Sch Publ Hlth, Dept Kinesiol, 1025 E 7th St,Suite 112, Bloomington, IN 47405 USA

[2] Univ Rochester, Dept Emergency Med, Med Ctr, 200 E River Rd, Rochester, NY 14623 USA

[3] Monash Univ, Alfred Ctr, Dept Neurosci, Level 6,99 Commercial Rd, Melbourne, Vic 3004, Australia

[4] Univ Melbourne, Dept Med, Clin Sci Bldg,4th Floor,300 Grattan St, Parkville, Vic 3050, Australia

[5] Indiana Univ, Coll Arts & Sci, Program Neurosci, 1101 E 10th St, Bloomington, IN 47405 USA

关键词: Blood biomarkers;    Traumatic brain injury;    Proteomics;    Metabolomics;    microRNA;    Extracellular vesicles;   

DOI  :  10.1016/j.neubiorev.2021.08.029

来源: Elsevier

【 摘 要 】

HUIBREGTSE, M.E, Bazarian, J.J., Shultz, S.R., and Kawata K. The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury. NEUROSCI BIOBEHAV REV XX (130) XXX-XXX, 2021.Blood biomarkers can serve as objective measures to gauge traumatic brain injury (TBI) severity, identify patients at risk for adverse outcomes, and predict recovery duration, yet the clinical use of blood biomarkers for TBI is limited to a select few and only to rule out the need for CT scanning. The biomarkers often examined in neurotrauma research are proteomic markers, which can reflect a range of pathological processes such as cellular damage, astrogliosis, or neuroinflammation. However, proteomic blood biomarkers are vulnerable to degradation, resulting in short half-lives. Emerging biomarkers for TBI may reflect the complex genetic and neurometabolic alterations that occur following TBI that are not captured by proteomics, are less vulnerable to degradation, and are comprised of microRNA, extracellular vesicles, and neurometabolites. Therefore, this review aims to summarize our understanding of how biomarkers for brain injury escape the brain parenchymal space and appear in the bloodstream, update recent research findings in several proteomic biomarkers, and characterize biological significance and examine clinical utility of microRNA, extracellular vesicles, and neurometabolites.

【 授权许可】

Free