Event-related potentials and cognition in Parkinson's disease: An integrative review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:71

Review

Seer, Caroline¹  Lange, Florian¹  Georgiev, Dejan^2,3  Jahanshahi, Marjan²  Kopp, Bruno¹ 

[1] Hannover Med Sch, Dept Neurol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1E 6BT, England

[3] Univ Med Ctr Ljubljana, Dept Neurol, Ljubljana, Slovenia

关键词: Parkinson's disease;    Cognition;    Dementia;    Executive function;    Basal ganglia;    Dopamine;    Event-related potentials (ERPs);    P3;    P3a;    P3b;    MMN;    NoGo-P3;    N2;    N-e/ERN;   

DOI  :  10.1016/j.neubiorev.2016.08.003

来源: Elsevier

【 摘 要 】

Cognitive impairment is a common non-motor symptom of Parkinson's disease (PD), but the nature of cognitive changes varies considerably between individuals. According to the dual-syndrome hypothesis, one cluster of patients is characterized by deficits in executive function that may be related to frontostriatal dysfunction. Other patients primarily show non-frontal cognitive impairments that progress rapidly to PD dementia (PDD). We provide a comprehensive review of event-related potential (ERP) studies to identify ERP measures substantiating the heterogeneity of cognitive impairment in PD. Our review revealed evidence for P3b and mismatch-negativity alterations in PDD, but not in non-demented PD, indicating that alterations of these ERPs constitute electrophysiological markers for PDD. In contrast, ERP correlates of executive functions, such as NoGo-P3, N2, and error(-related) negativity (N-e/ERN), appear to be attenuated in non-demented PD patients in a dopamine-dependent manner. Hence, ERP measures confirm and yield distinct electrophysiological markers for the heterogeneity of cognitive impairment in PD. We discuss limitations and open questions of the ERP approach and provide directions and predictions for future ERP research. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free