The hidden side of Parkinson's disease: Studying pain, anxiety and depression in animal models

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:96

Review

Faivre, Fanny¹  Joshi, Anil¹  Bezard, Erwan^2,3  Barrot, Michel¹ 

[1] Univ Strasbourg, Inst Neurosci Cellulaires & Integrat, CNRS, F-67000 Strasbourg, France

[2] Univ Bordeaux, Inst Malad Neurodegenerat, UMR 5293, F-33000 Bordeaux, France

[3] CNRS, UMR 5293, Inst Malad Neurodegenerat, F-33000 Bordeaux, France

关键词: Parkinson's disease;    Non-motor symptoms;    Pain;    Anxiety;    Depression;   

DOI  :  10.1016/j.neubiorev.2018.10.004

来源: Elsevier

【 摘 要 】

Parkinson's disease is a neurodegenerative disease leading to the loss of midbrain dopamine neurons. It is well known and characterized by motor symptoms that are secondary to the loss of dopamine innervation, but it is also accompanied by a range of various non-motor symptoms, including pain and psychiatric disorders such as anxiety and depression. These non-motor symptoms usually appear at early stages of the disease, sometimes even before the first motor symptoms, and have a dramatic impact on the quality of life of the patients. We review here the present state-of-the-art concerning pain, anxiety and depression-like parameters in animal models of Parkinson's disease.

【 授权许可】

Free