Chronic methamphetamine self-administration disrupts cortical control of cognition

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:69

Review

Bernheim, Aurelien¹  See, Ronald E.²  Reichel, Carmela M.¹ 

[1] Med Univ South Carolina, Dept Neurosci, 173 Ashley Ave,BSB 416B, Charleston, SC 29425 USA

[2] Westmont Coll, Dept Psychol, Santa Barbara, CA USA

关键词: Addiction;    Methamphetamine;    Cognitive deficits;    Prefrontal;    Perirhinal;    Glutamate;    Attention;    Object recognition;   

DOI  :  10.1016/j.neubiorev.2016.07.020

来源: Elsevier

【 摘 要 】

Methamphetamine (meth) is one of the most abused substances worldwide. Chronic use has been associated with repeated relapse episodes that may be exacerbated by cognitive impairments during drug abstinence. Growing evidence demonstrates that meth compromises prefrontal cortex activity, resulting in persisting attentional and memory impairments. After summarizing recent studies of meth-induced cognitive dysfunction using a translationally relevant model of self-administered meth, this review emphasizes the cortical brain changes contributing to cognitive dysregulation during abstinence. Finally, we propose the use of cognitive enhancers during abstinence that may promote a drug-free state by reversing cortical dysfunction linked with prolonged meth abuse. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free