Exercise training and detraining effects on body composition, muscle strength and lipid, inflammatory and oxidative markers in breast cancer survivors under tamoxifen treatment

LIFE SCIENCES

卷:284

Article

Ferreira de Jesus Leite, Marco Aurelio¹  Mariano, Igor Moraes¹  Costa Dechichi, Juliene Goncalves¹  Giolo, Jessica Sanjuliao¹  Goncalves, Alisson de Carvalho²  Puga, Guilherme Morais¹ 

[1] Univ Fed Uberlandia, Fac Phys Educ, Lab Cardioresp & Metab Physiol, Uberlandia, MG, Brazil

[2] Univ Fed Triangulo Mineiro, Nutr Dept, Uberaba, MG, Brazil

关键词: Breast Cancer;    Resistance training;    Oxidative stress;    Menopause;   

DOI  :  10.1016/j.lfs.2021.119924

来源: Elsevier

【 摘 要 】

Aims: The present study aimed to verify the effects of resistance training (RT) and successive detraining on body composition, muscle strength and lipid profile as primary outcome, and the oxidative stress and inflammatory markers as second outcome of postmenopausal Breast Cancer (BC) survivors undergoing tamoxifen (TA). Main methods: Fourteen postmenopausal BC survivors underwent 12 weeks of resistance exercise training and subsequently 12 weeks of detraining. Anthropometric parameters, lipid profile, muscle strength, inflammatory cytokines and the oxidative stress markers, were assessed before, after the training period and after detraining period. Key findings: One-way ANOVA showed that fat mass decrease (39.4 +/- 6.9 to 37.7 +/- 6.8%) and free-fat mass increase (39.3 +/- 4.9 to 40.3 +/- 5.6%) after RT. Muscle strength increased in response to training but decreased after the detraining period. Triglycerides (156 +/- 45 to 123 +/- 43 mg/dL) and total cholesterol (202 +/- 13 to 186 +/- 16 mg/dL) decreased after the RT and HDL-cholesterol (47 +/- 9 to 56 +/- 9 mg/dL) increased after RT and remained higher (53 + 10 mg/dL) than after detraining. IL-6 increases (24.65 +/- 10.85 to 41.42 +/- 22.88 pg/mL) and IL-17 (2.42 +/- 0.32 to 1.69 +/- 0.19 pg/mL), TBARS (1.91 +/- 0.19 to 1.03 +/- 0.1 mu mol/L), SOD (24.65 +/- 10.85 to 41.42 +/- 22.88 U/gHb) and Catalase activity (445.9 +/- 113.0 to 345.8 +/- 81.7 k/gHb.s) reduced after RT and remained lower after detraining. Significance: Resistance exercise training improves health markers of BC survivors undergoing TA and detraining are not sufficient to reverse the positive effects in oxidative stress markers.

【 授权许可】

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