Changes in polyphenol serum levels and cognitive performance after dietary supplementation with Concord grape juice in veterans with Gulf War Illness

LIFE SCIENCES

卷:292

Article

Van Doren, William W.¹  Iqbal, Umar Haris²  Helmer, Drew A.^1,3  Litke, David R.^1,4  Simon, James E.⁵  Wu, Qingli⁵  Zhao, Danyue⁵  Yin, Zhiya⁵  Ho, Lap²  Osinubi, Omowunmi^1,6  Pasinetti, Giulio Maria^2,7 

[1] Vet Affairs New Jersey Hlth Care Syst, War Related Illness & Injury Study Ctr, 385 Tremont Ave, E Orange, NJ 07018 USA

[2] Icahn Sch Med Mt Sinai, 1 Gustave L Levy Pl, New York, NY 10029 USA

[3] Michael E DeBakey VA Med Ctr, Ctr Innovat Qual Effectiveness & Safety, 2002 Holcombe Blvd, Houston, TX 77030 USA

[4] NYU, Dept Rehabil Med, Sch Med, 550 1St Ave, New York, NY 10016 USA

[5] Rutgers State Univ, Sch Environm & Biol Sci, New Use Agr & Nat Plant Prod Program, 59 Dudley Rd, New Brunswick, NJ 08901 USA

[6] Rutgers State Univ, Dept Environm & Occupat Hlth, Sch Publ Hlth, 683 Hoes Lane West, Piscataway, NJ 08854 USA

[7] James J Peters VA Med Ctr, 130 West Kingsbridge Rd, Bronx, NY 10468 USA

关键词: Gulf War Illness;    Dietary polyphenols;    Cognitive functioning;    Bioavailability;    Veterans;    Conjugate metabolites;   

DOI  :  10.1016/j.lfs.2021.119797

来源: Elsevier

【 摘 要 】

Aims: We investigated whether the consumption of Concord grape juice (CGJ) was associated with increased bioavailability of serum metabolites and their potential impact on cognitive performance in Veterans with Gulf War Illness (GWI).Main methods: Twenty-six veterans were selected from a cohort of 36 enrolled in a 24-week randomized, double-blind, Phase I/IIA clinical trial exploring whether the consumption of Concord grape juice (CGJ) was tolerable and safe in Veterans with GWI and improved cognitive function and fatigue. These 26 veterans were selected based on their completion of the entire 24-week protocol and documented adherence to the study beverage & GE;80%. Differences in serum metabolite levels between CGJ and placebo at midpoint and endpoint were evaluated using two-way repeated measures ANOVA with post hoc Sidak's multiple comparison test. Bivariate correlations to assess for possible relationships between change in serum metabolite levels and change in cognitive function as measured by the Halstead Category Test-Russell Revised Version (RCAT) were also conducted.Key findings: Seventy-six metabolites were identified and quantified in this study, with three (cyanidin-glucuronide, me-cyanidin-glucuronide, and me-malvidin-glucuronide) found to be significantly higher (p < 0.05) in the CGJ group compared to placebo at 24 weeks. Significant associations between changes in cognitive function and changes in serum levels of epicatechin-sulphate (r = 0.48, p = 0.01) and petunidin-glucuronide (r = 0.53, p < 0.01) from baseline to 24 weeks were also observed.Significance: Our data suggest that dietary supplementation with CGJ is associated with increased bioavailability of specific phenolic metabolites, some of which may be correlated with cognitive performance.

【 授权许可】

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