Extracellular matrix roles during cardiac repair

LIFE SCIENCES

卷:87

Review

Jourdan-LeSaux, Claude¹  Zhang, Jianhua¹  Lindsey, Merry L.¹ 

[1] Univ Texas Hlth Sci Ctr San Antonio, Div Cardiol, Dept Med, San Antonio, TX 78229 USA

关键词: Extracellular matrix;    Left ventricular remodeling;    Matrix metalloproteinases;    Inflammation;    Fibrosis;   

DOI  :  10.1016/j.lfs.2010.07.010

来源: Elsevier

【 摘 要 】

The cardiac extracellular matrix (ECM) provides a platform for cells to maintain structure and function, which in turn maintains tissue function. In response to injury, the ECM undergoes remodeling that involves synthesis, incorporation, and degradation of matrix proteins, with the net outcome determined by the balance of these processes. The major goals of this review are a) to serve as an initial resource for students and investigators new to the cardiac ECM remodeling field, and b) to highlight a few of the key exciting avenues and methodologies that have recently been explored. While we focus on cardiac injury and responses of the left ventricle (LV), the mechanisms reviewed here have pathways in common with other wound healing models. (C) 2010 Elsevier Inc. All rights reserved.

【 授权许可】

Free