The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review

LIFE SCIENCES

卷:244

Review

Yaribeygi, Habib¹  Maleki, Mina²  Sathyapalan, Thozhukat³  Iranpanah, Helia⁴  Orafai, Hossein M.^5,6  Jamialahmadi, Tannaz^7,8  Sahebkar, Amirhossein^9,10,11 

[1] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran

[2] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran

[3] Univ Hull, Hull York Med Sch, Acad Diabet Endocrinol & Metab, Kingston Upon Hull, N Humberside, England

[4] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran

[5] Univ Ahl Al Bayt, Fac Pharm, Dept Pharmaceut, Karbala, Iraq

[6] Al Zahraa Univ, Fac Pharm, Dept Pharmaceut, Karbala, Iraq

[7] Halal Res Ctr IRI, FDA, Tehran, Iran

[8] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran

[9] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948564, Razavi Khorasan, Iran

[10] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[11] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran

关键词: Diabetes mellitus;    Insulin resistance;    Insulin signal transduction;    Insulin sensitivity;    Calcitriol;    Vitamin D3;    Colecalciferol;   

DOI  :  10.1016/j.lfs.2020.117305

来源: Elsevier

【 摘 要 】

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.

【 授权许可】

Free