Role of the M1 receptor in regulating circadian rhythms

LIFE SCIENCES

卷:68

Article; Proceedings Paper

Gillette, MU ; Buchanan, GF ; Artinian, L ; Hamilton, SE ; Nathanson, NM ; Liu, C

关键词: acetylcholine;    cGMP/PKG signaling;    circadian rhythms;    muscarinic receptors;    suprachiasmatic nucleus;   

DOI  :  10.1016/S0024-3205(01)01040-2

来源: Elsevier

【 摘 要 】

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M-1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. (C) 2001 Elsevier Science Inc. All rights reserved.

【 授权许可】

Free