Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke

LIFE SCIENCES

卷:274

Review

Sharma, Sejal¹  Nozohouri, Saeideh¹  Vaidya, Bhuvaneshwar¹  Abbruscato, Thomas¹ 

[1] Texas Tech Univ, Hlth Sci Ctr TTUHSC, Jerry H Hodge Sch Pharm, Dept Pharmaceut Sci, Amarillo, TX USA

关键词: Metformin;    Anti- aging;    Neurodegenerative diseases;    Ischemic stroke;    Tobacco smoking;    Electronic cigarette vaping;    Diabetes;   

DOI  :  10.1016/j.lfs.2021.119343

来源: Elsevier

【 摘 要 】

Aging is a risk factor for major central nervous system (CNS) disorders. More specifically, aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact on neurovascular unit (NVU). Metformin, a first line FDA-approved anti-diabetic drug, has gained increasing interest among researchers for its role in improving aging-related neurodegenerative disorders. Additionally, numerous studies have illustrated metformin's role in ischemic stroke, a cerebrovascular disorder in which the NVU becomes dysfunctional which can lead to permanent life-threatening disabilities. Considering metformin's beneficial preclinical actions on various disorders, and the drug's role in alleviating severity of these conditions through involvement in commonly characterized cellular pathways, we discuss the potential of metformin as a suitable drug candidate for repurposing in CNS disorders.

【 授权许可】

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