Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:427

Article

Crippa, Federica¹  Moore, Thomas L.¹  Mortato, Mariangela¹  Geers, Christoph¹  Haeni, Laetitia¹  Hirt, Ann M.²  Rothen-Rutishauser, Barbara¹  Petri-Fink, Alke^1,3 

[1] Univ Fribourg, Adolphe Merkle Inst, Chemin Verdiers 4, CH-1700 Fribourg, Switzerland

[2] Swiss Fed Inst Technol, Inst Geophys, Sonneggstr 5, CH-8092 Zurich, Switzerland

[3] Univ Fribourg, Dept Chem, Chemin Musee 9, CH-1700 Fribourg, Switzerland

关键词: Magnetic hydrogels;    Magnetic nanoparticles;    Hyperthermia;    Stimuli-responsive substrates;    Mechanobiology;   

DOI  :  10.1016/j.jmmm.2016.11.023

来源: Elsevier

【 摘 要 】

Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic thermo-responsive nanocomposite substrates that undergo cyclical swelling and de-swelling phases when actuated by an alternating magnetic field in aqueous environment. The synthetized substrates are obtained with a facile and reproducible method from poly-N-isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their conformation and the temperature-related, magnetic, and biological behaviors were characterized via scanning electron microscopy, swelling ratio analysis, vibrating sample magnetometry, alternating magnetic field stimulation and indirect viability assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and exhibited swelling/deswelling behavior near physiological temperatures (around 34 degrees C). Therefore these magnetic thermo-responsive hydrogels are promising materials as stimuli-responsive substrates allowing the study of cell-behavior by changing the hydrogel properties in situ.

【 授权许可】

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