An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:377

Article

Bruvera, I. J.¹  Hernandez, R.²  Mijangos, C.²  Goya, G. F.^1,3 

[1] Univ Zaragoza, INA, Zaragoza 50018, Spain

[2] CSIC, Inst Ciencia & Tecnol Polimeros, E-28006 Madrid, Spain

[3] Univ Zaragoza, Fac Sci, Dept Condensed Matter Phys, E-50009 Zaragoza, Spain

关键词: Drug release;    Magnetic nanoparticies;    Magnetic hyperthermia;    Hydrogels;   

DOI  :  10.1016/j.jmmm.2014.10.149

来源: Elsevier

【 摘 要 】

We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) x 10(-9) g, demonstrating the potential of this device for very precise quantitative control of drug release. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free