Novel hydrogels containing Nafion and poly(ethylene oxide) based block copolymers

POLYMER

卷:114

Article

Fernandes, D.¹  Kluska, W.¹  Stanislawska, J.¹  Board, B.¹  Krysmann, M. J.²  Kelarakis, A.¹ 

[1] Univ Cent Lancashire, Sch Phys Sci & Comp, Ctr Mat Sci, Preston PR1 2HE, Lancs, England

[2] Univ Cent Lancashire, Sch Pharm & Biosci, Preston PR1 2HE, Lancs, England

关键词: Nafion;    Pluronics;    Poly(ethylene oxide);    Hydrogels;    Injectable;    Drug release;   

DOI  :  10.1016/j.polymer.2017.02.094

来源: Elsevier

【 摘 要 】

We present a novel family of biocompatible hydrogels containing Nafion and poly(ethylene oxide) based block copolymers. In aqueous environment, thermodynamically stable ionomer-copolymer complexes are formed, as evident by light scattering and quartz crystal microbalance experiments. Moreover, incorporation of Nafion dramatically modifies the phase behaviour and the rheological properties of copolymer hydrogels. The hybrid systems not only undergo sharp and thermally reversible sol-gel transitions below the body temperature, thus retaining their injectable nature, but they also generate mechanically robust hydrogels. Moreover, ibuprofen was continuously released over a period of 26 days for the Nafion/Pluronic hydrogel, compared to only 3 days for the Nafion-free system. The hybrid gels are promising candidates for 3D-bioprinting and controlled drug release applications. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free