The behaviors of ferromagnetic nano-particles in and around blood vessels under applied magnetic fields

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:323

Article

Nacev, A.^1,2  Beni, C.²  Bruno, O.²  Shapiro, B.^1,3,4 

[1] Fischell Dept Bioengn, College Pk, MD USA

[2] CALTECH, Pasadena, CA 91125 USA

[3] Inst Syst Res, College Pk, MD USA

[4] Univ Maryland, College Pk, MD USA

关键词: Magnetic drug targeting;    Ferromagnetic nanoparticles;    Simulations;    Tissue;    Blood vessels;    Treatment depth;    Non-dimensional parameters;    In-vivo experiments;   

DOI  :  10.1016/j.jmmm.2010.09.008

来源: Elsevier

【 摘 要 】

In magnetic drug delivery, therapeutic magnetizable particles are typically injected into the blood stream and magnets are then used to concentrate them to disease locations. The behavior of such particles in-vivo is complex and is governed by blood convection, diffusion (in blood and in tissue ), extravasation, and the applied magnetic fields. Using physical first-principles and a sophisticated vessel-membrane-tissue (VMT) numerical solver, we comprehensively analyze in detail the behavior of magnetic particles in blood vessels and surrounding tissue. For any blood vessel (of any size, depth, and blood velocity) and tissue properties, particle size and applied magnetic fields, we consider a Krogh tissue cylinder geometry and solve for the resulting spatial distribution of particles. We find that there are three prototypical behaviors (blood velocity dominated, magnetic force dominated, and boundary layer formation) and that the type of behavior observed is uniquely determined by three non-dimensional numbers (the magnetic-Richards on number, mass Peclet number, and Renkin reduced diffusion coefficient). Plots and equations are provided to easily read out which behavior is found under which circumstances (Figs. 5-8). We compare our results to previously published in-vitro and in-vivo magnetic drug delivery experiments. Not only do we find excellent agreement between our predictions and prior experimental observations , but we are also able to qualitatively and quantitatively explain behavior that was previously not understood. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free