Analysis of driven nanorod transport through a biopolymer matrix

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:380

Article; Proceedings Paper

Mair, Lamar O.¹  Weinberg, Irving N.¹  Nacev, Alek¹  Urdaneta, Mario G.¹  Stepanov, Pavel¹  Hilaman, Ryan¹  Himelfarb, Stephanie¹  Superfine, Richard² 

[1] Weinberg Med Phy LLC, Bethesda, MD 20817 USA

[2] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA

关键词: Magnetophoresis;    Magnetic nanorods;    Particle tracking;    Extracellular matrix;   

DOI  :  10.1016/j.jmmm.2014.09.059

来源: Elsevier

【 摘 要 】

Applying magnetic fields to guide and retain drug-loaded magnetic particles in vivo has been proposed as a way of treating illnesses. Largely, these efforts have been targeted at tumors. One significant barrier to long range transport within tumors is the extracellular matrix (ECM). We perform single particle measurements of 18 nm diameter nanorods undergoing magnetophoresis through ECM, and analyze the motion of these nanorods in two dimensions. We observe intra-particle magnetophoresis in this viscoelastic environment and measure the fraction of time these nanorods spend effectively hindered, versus effectively translating. (C) 2014 Elsevier B.V. All rights reserved,

【 授权许可】

Free