Theory for nanoparticle retention time in the helical channel of quadrupole magnetic field-flow fractionation

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:321

Article; Proceedings Paper

Williams, P. Stephen¹  Carpino, Francesca¹  Zborowski, Maciej¹ 

[1] Cleveland Clin, Lerner Res Inst, Dept Biomed Engn, Cleveland, OH 44195 USA

关键词: Field-flow fractionation;    Magnetic field-flow fractionation;    MgFFF;    Magnetic nanoparticles;    Nanoparticle characterization;    Quadrupole magnetic field;    Helical channel;   

DOI  :  10.1016/j.jmmm.2009.02.065

来源: Elsevier

【 摘 要 】

Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and sample components therefore have angular and longitudinal components to their motion in the thin annular space occupied by the helical channel. The retention ratio is defined as the ratio of the times for non-retained and a retained material to pass through the channel. Equations are derived for the respective angular and longitudinal components to retention ratio. (c) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free