Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study

PSYCHONEUROENDOCRINOLOGY

卷:43

Article

Nevell, Lisa¹  Zhang, Kezhong^1,2  Aiello, Allison E.³  Koenen, Karestan⁴  Galea, Sandro⁴  Soliven, Richelo¹  Zhang, Chao¹  Wildman, Derek E.^1,5  Uddin, Monica^1,6 

[1] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA

[3] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA

[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[5] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[6] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

关键词: Endoplasmic reticulum stress;    Unfolded protein response;    Epidemiology;    Matched-pair analysis;    Case-control studies;    Gene expression pattern analysis;    Cardiovascular diseases;    Metabolic diseases;   

DOI  :  10.1016/j.psyneuen.2014.01.013

来源: Elsevier

【 摘 要 】

Background: The role of endoplasmic reticulum (ER) stress response in mental illness is not well understood. Human studies and animal models of depression show elevated brain ER stress response. In addition, some ER stress associated disorders (e.g. cardiovascular disease) show higher rates of depression compared to the general population, raising the possibility that ER stress response contributes to depression risk. It remains unknown, however, if ER stress response is present among individuals suffering from other stress-related mental illness, and whether such a response would be evident in a non-clinical sample. This study tests for systemic changes in ER stress response associated with Major Depressive Disorder (MDD) or post-traumatic stress disorder (PTSD) among community-dwelling individuals. Methods: We analyzed expression of BiP, EDEM1, CHOP, and XBP1, the major indicators of ER stress response, with real-time PCR in leukocyte-derived RNA samples from 86 participants of the Detroit Neighborhood Health Study. Participants were selected based on the presence of either past year MDD or past year PTSD; controls were age and sex matched.

【 授权许可】

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