Secretory IgA reactivity to social threat in youth: Relations with HPA, ANS, and behavior

PSYCHONEUROENDOCRINOLOGY

卷:59

Article

Laurent, Heidemarie K.^1,2  Stroud, Laura R.^3,4,5  Brush, Bridget^3,4,5  D'Angelo, Christina^3,4,5  Granger, Douglas A.^2,6,7 

[1] Univ Oregon, Dept Psychol, Eugene, OR 97403 USA

[2] Arizona State Univ, Inst Interdisciplinary Salivary Biosci Res, Tempe, AZ 85281 USA

[3] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA

[4] Brown Univ, Miriam Hosp, Ctr Behav Med, Providence, RI 02912 USA

[5] Brown Univ, Miriam Hosp, Ctr Prevent Med, Providence, RI 02912 USA

[6] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA

[7] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA

关键词: SIgA;    Immunity;    Stress;    Children;    Adolescents;    Externalizing;    Cortisol;    sAA;   

DOI  :  10.1016/j.psyneuen.2015.04.021

来源: Elsevier

【 摘 要 】

Although the role of immune marker secretory immunoglobulin A (SIgA) in stress-related health outcomes is gaining recognition, SIgA responsiveness to acute stress has rarely been assessed in adults, and not at all in children. This study was designed to clarify developmental origins of differential immune function-related health risks by investigating youth SIgA responses to psychosocial stressors, including both normative responses and variability related to behavioral problems. Children and adolescents from a larger study (n = 82) gave 6 saliva samples during a laboratory session in which they were exposed to a series of performance or interpersonal stressors. Samples were assayed for SIgA, as well as cortisol (representing hypothalamic pituitary adrenal axis activity) and alpha-amylase (sAA; representing autonomic nervous system activity). Behavioral problems were assessed with parent-report measures of youth internalizing and externalizing. Youth SIgA trajectories followed a normative pattern of reactivity and recovery around the stressors; however, these responses were blunted in youth with higher externalizing scores. SIgA showed differential associations with cortisol and sAA, and with positive and negative affect; whereas overall levels of SIgA related to cortisol output and positive affect, changes in SIgA over time synchronized with changes in sAA and negative affect. In contrast to SIgA, neither cortisol nor sAA related significantly to behavioral problems. Implications for the role of SIgA during psychosocial stress in the development of immune function-related health risks are discussed. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free