Acute psychological stress increases serum circulating cell-free mitochondrial DNA

PSYCHONEUROENDOCRINOLOGY

卷:106

Article

Trumpff, Caroline^1,2  Marsland, Anna L.³  Basualto-Alarcon, Carla^4,5  Martin, James L.⁶  Carroll, Judith E.⁷  Sturm, Gabriel¹  Vincent, Amy E.⁸  Mosharov, Eugene V.^1,2,9  Gu, Zhenglong¹⁰  Kaufman, Brett A.⁶  Picard, Martin^1,9,11 

[1] Columbia Univ, Irving Med Ctr, Div Behav Med, Dept Psychiat, New York, NY 10032 USA

[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[3] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[4] Univ Aysen, Coyhaique, Chile

[5] Univ Chile, Fac Med, Anat & Legal Med Dept, Santiago, Chile

[6] Univ Pittsburgh, Med Sch, Ctr Metab & Mitochondrial Med, Dept Med,Div Cardiol,Vasc Med Inst, Pittsburgh, PA 15261 USA

[7] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA

[8] Newcastle Univ, Inst Neurosci, Wellcome Trust Ctr Mitochondrial Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[9] Columbia Univ, Irving Med Ctr, Columbia Translat Neurosci Initiat, Dept Neurol,H Houston Merritt Ctr, New York, NY 10032 USA

[10] Cornell Univ, Div Nutr Sci, Ithaca, NY 14850 USA

[11] Columbia Univ, Mailman Sch Publ Hlth, Columbia Aging Ctr, New York, NY 10032 USA

关键词: Psychosocial stress;    Mitochondria;    Neuroendocrine;    Mitokine;    Psychobiology;    Cell-free DNA;   

DOI  :  10.1016/j.psyneuen.2019.03.026

来源: Elsevier

【 摘 要 】

Intrinsic biological mechanisms transduce psychological stress into physiological adaptation that requires energy, but the role of mitochondria and mitochondrial DNA (mtDNA) in this process has not been defined in humans. Here, we show that similar to physical injury, exposure to psychological stress increases serum circulating cell-free mtDNA (ccf-mtDNA) levels. Healthy midlife adults exposed on two separate occasions to a brief psychological challenge exhibited a 2-3-fold increase in ccf-mtDNA, with no change in ccf-nuclear DNA levels, establishing the magnitude and specificity for ccf-mtDNA reactivity. In cell-based studies, we show that glucocorticoid signaling - a consequence of psychological stress in humans - is sufficient to induce mtDNA extrusion in a time frame consistent with stress-induced ccf-mtDNA increase. Collectively, these findings provide evidence that acute psychological stress induces ccf-mtDNA and implicate neuroendocrine signaling as a potential trigger for ccf-mtDNA release. Further controlled work is needed to confirm that observed increases in ccf-mtDNA result from stress exposure and to determine the functional significance of this effect.

【 授权许可】

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